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The 3-aminopyridazine pharmacophore, in particular, allowed him to accede to an impressive variety of biological activities, including antidepressant and anticonvulsant molecules; inhibitors of enzymes such as mono-amine-oxidases, phosphodiesterases and acetylcholinesterase; ligands for neuro-receptors: GABA-A receptor antagonists, serotonine 5-HT3 receptor antagonists, dopaminergic and muscarinic agonists.

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More recently, in collaboration with the scientists of the Sanofi Company, he developed potent antagonists of the 41 amino-acid neuropeptide CRF corticotrophin-releasing factor which regulates the release of ACTH and thus the synthesis of corticoids in the adrenal glands. After a three-year exploratory phase, this research has led to nanomolar partial agonists which may prove useful in the treatment of the cocaine-withdrawal syndrome.

Wermuth is co-author or editor of several books, the author of over scientific papers and holds nearly 60 patents.

The Practice of Medicinal Chemistry. The Practice of Medicinal Chemistry, 2E, is a single-volume source on the practical aspects of medicinal chemistry.

What is MEDICINAL CHEMISTRY? What does MEDICINAL CHEMISTRY mean? MEDICINAL CHEMISTRY meaning

The successful first edition was nicknamed "The Bible" by medicinal chemists, and the second edition has been updated, expanded and refocused to reflect developments over the last decade. Emphasis is put on how medicinal chemists conduct their search for and design of new drug entities. In contrast to competing books, it focuses on the chemistry rather than pharmacological concepts or descriptions of the various therapeutic classes of drugs.

Wermuth is co-author or editor of several books, the author of over scientific papers and holds nearly 60 patents. The Practice of Medicinal Chemistry.

The practice of medicinal chemistry

The Practice of Medicinal Chemistry, 2E, is a single-volume source on the practical aspects of medicinal chemistry. The successful first edition was nicknamed "The Bible" by medicinal chemists, and the second edition has been updated, expanded and refocused to reflect developments over the last decade.


  1. Medicinal Chemistry Books 2017!
  2. Douglas Chaves de Alcântara Pinto;
  3. The Practice of Medicinal Chemistry.

Emphasis is put on how medicinal chemists conduct their search for and design of new drug entities. In contrast to competing books, it focuses on the chemistry rather than pharmacological concepts or descriptions of the various therapeutic classes of drugs.

Most medicinal chemists working in the pharmaceutical industry are organic synthetic chemists who must acquire a strong knowledge of medicinal chemistry as they enter the industry. This book aims to be their practical handbook - a complete guide to the drug discovery process. The only book available dealing with the practical aspects of medicinal chemistry Serves as a complete guide to the drug discovery process, from conception of the molecules to drug production Updated chapters devoted to the discovery of new lead compounds, including combinatorial chemistry.